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This is an overestimation of real cost invoiced to the health system for several reasons: a prescription might be printed several times because of technical problems. Also, not all patients with a prescription go to the pharmacy store to get the drug. As a result of this, the real pharmacy cost invoiced to the health system is not as high as that obtained from the patient electronic file. In our study we estimated a deviation of 25, and an appropriate correction was applied when estimating the sources of variability.
Although the deviation is important, and it is a limitation of the study, we cannot analyse in detail these unfilled prescriptions because the real cost per person invoiced to the health system is not available.