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Conclusion In our setting, case-mix, measured with free information on option trading strategies ACG system, is the variable studied that explains more variability in prescription drug expenditure in adults. In pediatric population there is greater variability among physicians and centers which is not related to case-mix. The implementation of clinical guidelines might be helpful to reduce this variability. For our sites, ACG is a useful tool to analyze efficiency and compare physicians and centers when data are obtained from electronic records in real conditions of usual practice.
It is possible to identify physicians and centers with high expenditure but with a good efficiency index after adjusting for case-mix, and also centers and professionals with apparent low cost but considering their case mix, a lower expenditure would be expected.